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Moreover, it has been demonstrated in mouse models that the levels of 2,3-Bisphosphoglycerate (2,3-BPG) derived from 1,3-Bisphosphoglycerate (1,3-BPG) are significantly increased, which bypassed ATP-producing pathway where 13 BPG synthesizes 3-Bisphosphoglycerate (3-BPG) (5)

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